WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Vasopressin-regulated water reabsorption       ID:04962
C=44; O=4; E=0.13; R=30.39; rawP=9.45e-06; adjP=0.0003
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000111540 NA RAB5B RAB5B, member RAS oncogene family 5869 ENSG00000111540
2  ENSG00000158560 NA DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 1780 ENSG00000158560
3  ENSG00000162104 NA ADCY9 adenylate cyclase 9 115 ENSG00000162104
4  ENSG00000204843 NA DCTN1 dynactin 1 1639 ENSG00000204843


Database:KEGG pathway       Name:Endometrial cancer       ID:05213
C=52; O=3; E=0.16; R=19.29; rawP=0.0005; adjP=0.0031
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000140992 NA PDPK1 3-phosphoinositide dependent protein kinase-1 5170 ENSG00000140992
2  ENSG00000044115 NA CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 1495 ENSG00000044115
3  ENSG00000138798 NA EGF epidermal growth factor 1950 ENSG00000138798


Database:KEGG pathway       Name:mTOR signaling pathway       ID:04150
C=52; O=3; E=0.16; R=19.29; rawP=0.0005; adjP=0.0031
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000135932 NA CAB39 calcium binding protein 39 51719 ENSG00000135932
2  ENSG00000140992 NA PDPK1 3-phosphoinositide dependent protein kinase-1 5170 ENSG00000140992
3  ENSG00000198793 NA MTOR mechanistic target of rapamycin (serine/threonine kinase) 2475 ENSG00000198793


Database:KEGG pathway       Name:Focal adhesion       ID:04510
C=200; O=5; E=0.60; R=8.36; rawP=0.0004; adjP=0.0031
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000140992 NA PDPK1 3-phosphoinositide dependent protein kinase-1 5170 ENSG00000140992
2  ENSG00000116473 NA RAP1A RAP1A, member of RAS oncogene family 5906 ENSG00000116473
3  ENSG00000035403 NA VCL vinculin 7414 ENSG00000035403
4  ENSG00000138798 NA EGF epidermal growth factor 1950 ENSG00000138798
5  ENSG00000160007 NA ARHGAP35 Rho GTPase activating protein 35 2909 ENSG00000160007


Database:KEGG pathway       Name:Proteasome       ID:03050
C=44; O=3; E=0.13; R=22.79; rawP=0.0003; adjP=0.0031
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000175166 NA PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 5708 ENSG00000175166
2  ENSG00000173692 NA PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 5707 ENSG00000173692
3  ENSG00000103035 NA PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 5713 ENSG00000103035


Database:KEGG pathway       Name:Leukocyte transendothelial migration       ID:04670
C=116; O=4; E=0.35; R=11.53; rawP=0.0004; adjP=0.0031
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000116473 NA RAP1A RAP1A, member of RAS oncogene family 5906 ENSG00000116473
2  ENSG00000035403 NA VCL vinculin 7414 ENSG00000035403
3  ENSG00000044115 NA CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 1495 ENSG00000044115
4  ENSG00000160007 NA ARHGAP35 Rho GTPase activating protein 35 2909 ENSG00000160007


Database:KEGG pathway       Name:Protein processing in endoplasmic reticulum       ID:04141
C=165; O=4; E=0.49; R=8.10; rawP=0.0016; adjP=0.0074
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101152 NA DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 80331 ENSG00000101152
2  ENSG00000135018 NA UBQLN1 ubiquilin 1 29979 ENSG00000135018
3  ENSG00000119318 NA RAD23B RAD23 homolog B (S. cerevisiae) 5887 ENSG00000119318
4  ENSG00000182446 NA NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 55666 ENSG00000182446


Database:KEGG pathway       Name:Adherens junction       ID:04520
C=73; O=3; E=0.22; R=13.74; rawP=0.0014; adjP=0.0074
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101266 NA CSNK2A1 casein kinase 2, alpha 1 polypeptide 1457 ENSG00000101266
2  ENSG00000035403 NA VCL vinculin 7414 ENSG00000035403
3  ENSG00000044115 NA CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 1495 ENSG00000044115


Database:KEGG pathway       Name:Prostate cancer       ID:05215
C=89; O=3; E=0.27; R=11.27; rawP=0.0025; adjP=0.0103
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000140992 NA PDPK1 3-phosphoinositide dependent protein kinase-1 5170 ENSG00000140992
2  ENSG00000198793 NA MTOR mechanistic target of rapamycin (serine/threonine kinase) 2475 ENSG00000198793
3  ENSG00000138798 NA EGF epidermal growth factor 1950 ENSG00000138798


Database:KEGG pathway       Name:Endocytosis       ID:04144
C=201; O=4; E=0.60; R=6.65; rawP=0.0032; adjP=0.0118
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000006125 NA AP2B1 adaptor-related protein complex 2, beta 1 subunit 163 ENSG00000006125
2  ENSG00000111540 NA RAB5B RAB5B, member RAS oncogene family 5869 ENSG00000111540
3  ENSG00000181852 NA RNF41 ring finger protein 41 10193 ENSG00000181852
4  ENSG00000138798 NA EGF epidermal growth factor 1950 ENSG00000138798




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).